Study of the involvement of antigen cross-presentation in the antitumor activity of immunostimulatory monoclonal antibodies

Fecha: diciembre 2019
Alfonso Rodríguez Sánchez-Paulete
Estudios de la Fundación

Sumario

Agradecimientos
General introduction
Objectives
Results
Chapter 1. Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires BATF3-dependent dendritic cells
Chapter 2. Intratumoral immunotherapy with XCL1 and SFLT3L encoded in recombinant semliki forest virus-derived vectors to Foster dendritic cell-mediated t-cell crosspriming general discusión conclusions general bibliography
Annex 1. Review article. Antigen cross-presentation and t-cell cross-priming in cancer immunology and immunotherapy
Annex 2. Review article. Deciphering CD137 (4-1bb) signaling in t-cell costimulation for translation into successful cancer immunotherapy